Robust Network Topologies for Generating Switch-Like Cellular Responses
نویسندگان
چکیده
منابع مشابه
Robust Network Topologies for Generating Switch-Like Cellular Responses
Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component networks on random parameter sets, and assessed the resulting response profiles for both steepnes...
متن کاملRobust network topologies for generating oscillations with temperature-independent periods
Nearly all living systems feature a temperature-independent oscillation period in circadian clocks. This ubiquitous property occurs at the system level and is rooted in the network architecture of the clock machinery. To investigate the mechanism of this prominent property of the circadian clock and provide general guidance for generating robust genetic oscillators with temperature-compensated ...
متن کاملGenerating network topologies that obey power laws
Recent studies have shown that Internet graphs and other network systems follow power-laws. Do artiicial network topologies commonly used in network simulation studies obey these power-laws? In this paper we show that current topology generators do not obey all of the power-laws, and we present two new topology generators that do. Finally, we re-evaluate a multicast study to demonstrate the imp...
متن کاملManuscript: CL 2002-1133 Generating Realistic ISP-Level Network Topologies
Simulations are an important tool in network research. As the selected topology often influences the outcome of the simulation, realistic topologies are needed to produce realistic simulation results. Using several similarity metrics to compare artificially generated topologies with real world topologies this letter gives hints how to use the wide-spread topology generators BRITE, TIERS and GT-...
متن کاملSystematic Reverse Engineering of Network Topologies: A Case Study of Resettable Bistable Cellular Responses
A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse engineering procedure to identify network topologies with high likelihood in generating desired systems properties. Our method searches the continuous parameter space of an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2011
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002085